Heather Knight1,Yunjeong Park1,Sebastian Hernandez1,Cristian O. Hernandez1,Hunter E. Schweiger1,Houpu Li1,Kateryna Voitiuk1,Harika Dechiraju1,Nico Hawthorne1,Elana M. Muzzy1,John A. Selberg1,Frederika N. Sullivan1,Roberto Urcuyo1,Sofie R. Salama1,Elham Aslankoohi1,Mircea Teodorescu1,Mohammed A. Mostajo Radji1,Marco Rolandi1
University of California1
Heather Knight1,Yunjeong Park1,Sebastian Hernandez1,Cristian O. Hernandez1,Hunter E. Schweiger1,Houpu Li1,Kateryna Voitiuk1,Harika Dechiraju1,Nico Hawthorne1,Elana M. Muzzy1,John A. Selberg1,Frederika N. Sullivan1,Roberto Urcuyo1,Sofie R. Salama1,Elham Aslankoohi1,Mircea Teodorescu1,Mohammed A. Mostajo Radji1,Marco Rolandi1
University of California1
Cortical organoids are valuable tools for studying brain development, modeling neurological disorders, and testing potential treatments. For these studies, we need to improve the ability to precisely manipulate and modulate the activity of the cortical organoids at a fine time scale in a precise and detailed manner. Here, we have employed a bioelectronic approach with an ion pump, used for selective delivery of ions and neurotransmitters. More specifically, we used these devices to experimentally determine neuronal effects on the organoids with the bioelectronic delivery of potassium ions (K+), protons (H+), and γ-aminobutyric acid (GABA). This work is important to reflect bioelectronic device potential in exploring neurological disorders and their potential treatments with a level of precision and detail that was previously challenging to achieve.