Sydnie Figuerres1,2,Houpu Li1,2,Hsin-ya Yang1,2,Narges Asefifeyzabadi1,2,Prabhat Baniya1,2,Andrea Medina Lopez1,2,Anthony Gallegos1,2,Kan Zhu1,2,Hao-Chieh Hsieh1,2,Tiffany Nguyen1,2,Cristian O. Hernandez1,2,Ksenia Zlobina1,2,Cynthia Recendez1,2,Maryam Tebyani1,2,Hector Carrion1,2,John A. Selberg1,2,Le Luo1,2,Moyasar A. Alhamo1,2,Athena M. Soulika1,2,Michael Levin1,2,Narges Norouzi1,2,Marcella Gomez1,2,Min Zhao1,2,Mircea Teodorescu1,2,Roslyn Rivkah Isseroff1,2,Marco Rolandi1,2
University of California1,University of California, Davis2
Sydnie Figuerres1,2,Houpu Li1,2,Hsin-ya Yang1,2,Narges Asefifeyzabadi1,2,Prabhat Baniya1,2,Andrea Medina Lopez1,2,Anthony Gallegos1,2,Kan Zhu1,2,Hao-Chieh Hsieh1,2,Tiffany Nguyen1,2,Cristian O. Hernandez1,2,Ksenia Zlobina1,2,Cynthia Recendez1,2,Maryam Tebyani1,2,Hector Carrion1,2,John A. Selberg1,2,Le Luo1,2,Moyasar A. Alhamo1,2,Athena M. Soulika1,2,Michael Levin1,2,Narges Norouzi1,2,Marcella Gomez1,2,Min Zhao1,2,Mircea Teodorescu1,2,Roslyn Rivkah Isseroff1,2,Marco Rolandi1,2
University of California1,University of California, Davis2
The ability to deliver drugs with precise dosages at specific time points can significantly improve disease treatment while reducing side effects. Drug encapsulation for gradual delivery has opened up the doors for a superior treatment regimen. To expand on this ability, programming bioelectronic devices to deliver small molecules enables ad-hoc personalized therapeutic profiles that are more complex than gradual release. Here, we introduce a wearable bioelectronic bandage with an integrated electrophoretic ion pump that affords on-demand drug delivery with precise dose control. In this poster, I will present my contribution to the device fabrication that involves hydrogel synthesis in glass capillaries, testing of the hydrogel conductivity, and device testing. With these devices, delivery of fluoxetine to wounds in mice resulted in a 27.2% decrease in the macrophage ratio (M1/M2) and a 39.9% increase in reepithelialization, indicating a shorter inflammatory phase and faster overall healing. Programmable drug delivery using wearable bioelectronics in wounds introduces a broadly applicable strategy for the long-term delivery of a prescribed treatment regimen with minimal external intervention.