Acoustic Anti-Cancer Therapy Using Nanoparticles

Sonodynamic (SDT) has the advantage of localized anti-cancer treatment on the targeted tumor region and, can minimize the side effects for normal tissues. SDT is usually operated by ultrasound of 20 kHz or higher frequencies. However, biomedical research on audible soundwaves below 20kHz to control SDT were vailed. Herein, we report audible soundwaves that triggering the aggregation of the nanoparticles and, the aggregation behavior of the nanoparticles subsequently influenced the intracellular autophagy formation. Thus, the amplified autophagy by audible soundwave responsive nanodrug effectively increased apoptosis in cancer cells. In conclusion, obtained result clearly demonstrated the anti-cancer therapy using sub-audible ranges of frequency and suggested novel strategy for the treatment of anti-cancer therapy with noninvasive manner.