3D Printing using Oxygen-Generating Filaments for Bone Scaffold Tissue Engineering

The latest advancements in bone scaffold technology have introduced novel biomaterials that have the ability to generate oxygen when implanted, improving cell viability and tissue maturation. We developed a new oxygen-generating nanocomposite filament that can be used in FDM based 3D printing of bone tissue scaffolds. Initially, the polymer nanocomposites were characterised using an X-ray diffraction analysis, surface morphology assessment, evaluation of filament extrudability, microstructural analysis, and examination of their rheological and mechanical properties in order to optimized filament production. Next, the filaments were optimized in terms of nanocomposite content to control oxygen release, porosity, and antibacterial activities.Our results indicate that an optimized oxygen releasing filament with a holds great promise for improving bone generation through supporting bone cell oxygenation and resistance to bacterial infections.