Novel Two-Dimensional-Based Materials as Effective Electrothermal Agents for Advanced-Imaging-Enhanced Combination Cancer Therapy

In clinical studies, the utilization of electrothermal agent (ETA) in cancer electrothermal therapy has shown promising results. The safety concerns are addressed by the rapid degradation of ETAs, but the electrothermal stability required for efficacious treatment is limited. On the other hand, slow degradation occurs in ETAs with high electrothermal stability. Limited solutions exist to address the balance between the high electrothermal stability and rapid degradation of ETAs. Herein, we report that the assembly of novel two-dimensional (2D) material types can accelerate the degradation of 2D materials, while also maintaining high electrothermal stability. Moreover, by utilizing specified 2D materials archetypes, advanced imaging can be achieved for cancer monitoring. Thus, this work not only introduces an ‘ideal’ ETA that avoids the limitations of ETAs, but also provides the proof-of-concept application of 2D-based materials in advanced-imaging-facilitated combination cancer therapy.