Nano Herbals for Effective Wound Healing

<b>Background: </b>The demand for Pharmacognostic-based compounds with diverse pharmaceutical<br/>activities has been escalating to combat challenges like drug resistance, emerging diseases, and<br/>the toxicity of currently used chemical compounds. The plant kingdom offers a plethora of<br/>bioactive compounds with unprecedented potential to address these difficulties, leading to a<br/>surge in novel solutions within the pharmaceutical industry. Ayurvedic formulations of Tobacco<br/>(Nicotiana tabacum) have emerged as a promising approach due to their established use in herbal<br/>medicine with multiple medicinal benefits.<br/><br/><b>Methods: </b>This study aimed to explore the wound healing potential of the tobacco plant. Tobacco<br/>leaves were processed to create a traditional ayurvedic formulation, including Mashi<br/>formulations known as Anterdhum Padhati Mashi, Bahirdhum Padhati Mashi, and Muffle<br/>Furnace Mashi, following traditional ayurvedic practices. Additionally, aqueous, and alcoholic<br/>extracts of tobacco leaves were prepared. The wound healing efficacy of these formulations was<br/>assessed using an Excision model in mice.<br/><b>Results:</b> Comparative analysis revealed that the Bahirdhum Padhati Mashi with methanolic<br/>discharge exhibited significantly higher wound healing ability compared to a reference drug<br/>formulation.<br/><b>Conclusion:</b> In conclusion, the Bahirdhum Padhati Mashi derived from tobacco demonstrates<br/>promising wound healing potential and could serve as an effective wound healing agent. The<br/>findings from this experimental study support the exploration of ayurvedic formulations as<br/>potential candidates for addressing wound healing complications. Further investigations and<br/><br/>clinical trials are warranted to ascertain their safety, efficacy, and potential application in wound<br/>management.<br/><b>Keywords:</b> Nano particle, Nicotiana tabacum, wound healing, Anterdhum Padhati, Nano formulation, herbal nano formulation