The Operando SAXS Characterization of The Binary Mixing of F127/L121 Pluronic Biomedical Hydrogels in The Self-Assembly

Pluronic biomedical hydrogels (PBHs) was proposed to study the structural changes in the self-assembly of binary mixing copolymers. PBHs are served as a microenvironment and a as a targeted drug delivery system offering many attractive benefits such as intrinsic biocompatibility and controllable prolonged drug delivery.Small angle X-ray scattering (SAXS) was used to discover the self-assembled structures of the PBHs in real time with respect to the temperature variations. According to the SAXS results, structural changes of the micelle and the lamellar affected the mixing behavior of hydrophilic segments and hydrophobic segments. Thus, the transformation between the flat lamellar amphiphilic boundary and the hydrophobic core was studied. Results show that the diffusion of the amphiphilic segments in the PBHs will affect a lot across the interface between the hydrophilic corona and the hydrophobic core. Evidence are observed for the self-assembly of PBHs at the temperatures from 25 to 45 °C simultaneously.