Hydrogen Medicine and Nanomedicines

Hydrogen molecule has broad-spectrum anti-oxidation and anti-inflammation effects, and has exhibited clear therapeutic functions against many inflammation-related diseases and relatively high biosafety. Therefore, hydrogen therapy is an emerging and promising therapeutic strategy. But hydrogen medicine is currently facing three major issues, including (1) what is the fundamental principle of hydrogen therapy; (2) how to detect hydrogen molecules in vivo; (3) how to deliver hydrogen molecules to the focus in vivo. Aiming to these three issues, our research group has obtained a cascade of important research achievements in principle exploration, tool development, and materials application, mainly including (1) the discovery of the biological target of hydrogen molecule and the disclosure of the fundamental principle of its anti-inflammation, anti-cancer and anti-senescence functions; (2) the development of the first bioprobe of hydrogen molecule and the verification of the high biological barriers-crossing capability of hydrogen molecule; (3) the development of a series of novel biomedical materials for hydrogen delivery to enhance the efficiency of hydrogen delivery and their applications for the treatment of many major diseases. This lecture will deliver our recent research advances in these aspects.^[1-10]<br/><br/><b>Keywords:</b> Hydrogen medicine, targeted delivery, nanomedicine, molecular imaging, nanocatalytic medicine<br/><b>Reference</b><br/>Zhaokui Jin, Penghe Zhao, Wanjun Gong, Wenjiang Ding, Qianjun He, Fe-porphyrin: a redox-related biosensor of hydrogen molecule, <b><i>Nano Res.</i></b> 2023, 16, 2020.<br/>Shengqiang Chen, Yuanman Yu, Songqing Xie, Danna Liang, Wei Shi, Sizhen Chen, Guanglin Li, Wei Tang, Changsheng Liu, Qianjun He, Local H₂ release remodels senescence microenvironment for improved repair of injured bone, <b><i>Nat. Commun.</i></b> 2023, accepted in press.<br/>Qingqing Xu, Shengqiang Chen, Lingdong Jiang, Chao Xia, Lingting Zeng, Xiaoqing Cai, Zhaokui Jin, Shucun Qin, Wenjiang Ding, Qianjun He, Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing, <b><i>Natl. Sci. Rev.</i></b> 2023, 10, nwad063.<br/>Shengqiang Chen, Yanxia Zhu, Qingqing Xu, Qi Jiang, Danyang Chen, Ting Chen, Xishen Xu, Zhaokui Jin, Qianjun He, Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing, <b><i>Nat. Commun.</i></b> 2022, 13, 5684.<br/>Bin Zhao, Lingting Zeng, Danyang Chen, Songqing Xie, Zhaokui Jin, Guanglin Li, Wei Tang, Qianjun He, NIR-photocatalytic regulation of arthritic synovial microenvironment, <b><i>Sci. Adv.</i></b> 2022, 8, eabq0959.<br/>Wanjun Gong, Lingdong Jiang, Yanxia Zhu, Mengna Jiang, Danyang Chen, Zhaokui Jin, Shucun Qin, Zhiqiang Yu, Qianjun He, An activity-based ratiometric fluorescent probe for in vivo real-time imaging of hydrogen molecules, <b><i>Angew.</i></b> <b><i>Chem.</i></b> <b><i>Int.</i></b> <b><i>Ed.</i></b> 2022, 61, e202114594.<br/>Yangsen Xu, Mingjian Fan, Wenjuan Yang, Yonghao Xiao, Lingting Zeng, Xiao Wu, Qinghua Xu, Chenliang Su, Qianjun He, Homogenous carbon/potassium-incorporation strategy for synthesizing red polymeric carbon nitride capable of near-infrared-photocatalytic H₂ production, <b><i>Adv. Mater.</i></b> 2021, 33, 2101455.<br/>Bin Zhao, Yingshuai Wang, Xianxian Yao, Danyang Chen, Mingjian Fan, Zhaokui Jin, Qianjun He, Photocatalysis-mediated drug-free sustainable cancer therapy using nanocatalyst, <b><i>Nat. Commun.</i></b> 2021, 12, 1345.<br/>Yingshuai Wang, Tian Yang, Qianjun He, Strategies for engineering advanced nanomedicines for gas therapy of cancer, <b><i>Natl. Sci. Rev.</i></b> 2020, 7, 1485–1512.<br/>Penghe Zhao, Zhaokui Jin, Qian Chen, Tian Yang, Danyang Chen, Jin Meng, Xifeng Lu, Zhen Gu, Qianjun He, Local generation of hydrogen for enhanced photothermal therapy, <b><i>Nat. Commun.</i></b> 2018, 9, 4241.