Interrogation of Brain and Peripheral Organ Neurophysiology with Multifunctional Fibers

Over the past decade multifunctional fibers have been applied to recording and modulation of neuronal signaling in the central nervous system in behaving rodents. In this talk, I will first touch upon translational challenges associated with applying powerful fiber neurotechnology in large animal models as a steppingstone to applications in human patients. I will then discuss our recent efforts to create fiber-based probes suitable for interrogation of neuronal signaling in peripheral organs. For instance, applications of fiber-based probes to studies of enteric (gut) circuits will be discussed along with the materials challenges posed by the anatomy and physiology of the gastro-intestinal tract. I will further describe the translational efforts in applying peripheral fiber neurotechnology in large animal models and the potential therapeutic benefits that can be delivered by these biologically informed multifunctional tools in conditions with disrupted peripheral innervation. Together, this talk will highlight the promise and challenges of preclinical implementation of fiber-based neurotechnologies.