Cyclic Peptide/Polymer Conjugates for Therapeutic Applications

We describe the synthesis, characterisation and therapeutic applications of bioconjugate based on cyclic peptides covalently attached to well-controlled polymeric chains. The conjugates assemble into short nanotubes (20 to 200nm) through the stacking of the cyclic peptide motives, with functionality imparted by the polymeric chains. The resulting constructs show remarkable properties in terms of cell penetration, and <i>in vivo</i> biodistribution.