Plasmonic Nanostructures on Paper Test Strips for Acute Disease Testing

This talk will present our effort to develop plasmonic nanostructures toward testing of acute diseases such as traumatic brain injury, HIV and COVID-19. We tailor the chemical composition, microstructure and geometry of plasmonic metallic nanostructures to tune the optical mode of surface plasmonic resonance for light management. We construct surface-enhanced Raman spectroscopy (SERS) and fluorescence sensor and amplify optical signals with plasmon. Next, we incorporate plasmonic optical sensors into paper-based lateral flow assays to develop all-in-one test strips, which enables testing by laypersons at home, clinics and emergency departments.