Philipp Gutruf1
University of Arizona1
Materials and fabrication concepts for the creation of soft electronics coupled with miniaturization of wireless energy harvesting schemes enable the construction of high-performance electronic and optoelectronic systems with sizes, shapes and physical properties matched its biological host<sup>[1]</sup>. Applications range from continuous monitors for health diagnosis to minimally invasive exploratory tools for neuroscience<sup>[2]</sup>. Translation of these approaches towards neuroscience tools to enable advanced insight into the central and peripheral nervous require means to enable full subdermal implantation and operation to enable naturalistic behavior which often is the readout of circuit level behavioral experiments that are critical to decipher function. This talk presents science and engineering approaches for the creation of soft devices with near field power transfer and data communication capabilities<sup>[3]</sup> and discusses application in devices for the stimulation and recording of organ systems such as the brain, the peripheral nervous, cardiovascular and the musculoskeletal system. We introduce a series of advances in subdermally implantable device technologies that enable digitally controllable subdermal platforms with multimodal optogenetic and electrical stimulation capabilities<sup>[4]</sup><sup>[5]</sup> with the ability to provide stimulus without the physical penetration of the blood brain barrier. Additional to these stimulation capabilities we demonstrate new capabilities in biointerfaces with the cardiovascular and musculoskeletal system<sup>[6]</sup> that enable recording of organ health as well as closed loop operation chronically in freely moving subjects. Because of the minimally invasive nature of these tools we show chronic neuromodulation capabilities over months in freely moving subjects enabling a digital disease models as well as platforms that can be rapidly translated to large animal models.<br/>[1] T. Stuart, L. Cai, A. Burton, P. Gutruf, <i>Biosens. Bioelectron.</i> <b>2021</b>, 113007.<br/>[2] L. Cai, P. Gutruf, <i>J. Neural Eng.</i> <b>2021</b>, <i>18</i>, 41001.<br/>[3] P. Gutruf, V. Krishnamurthi, A. Vázquez-Guardado, Z. Xie, A. Banks, C.-J. Su, Y. Xu, C. R. Haney, E. A. Waters, I. Kandela, S. R. Krishnan, T. Ray, J. P. Leshock, Y. Huang, D. Chanda, J. A. Rogers, <i>Nat. Electron.</i> <b>2018</b>, <i>1</i>, 652.<br/>[4] A. Burton, S. M. Won, A. K. Sohrabi, T. Stuart, A. Amirhossein, J. U. Kim, Y. Park, A. Gabros, J. A. Rogers, F. Vitale, A. G. Richardson, P. Gutruf, <i>Microsystems Nanoeng.</i> <b>2021</b>, <i>7</i>, 62.<br/>[5] J. Ausra, S. J. Munger, A. Azami, A. Burton, R. Peralta, J. E. Miller, P. Gutruf, <i>Nat. Commun.</i> <b>2021</b>, <i>12</i>, 1968.<br/>[6] L. Cai, A. Burton, D. A. Gonzales, K. A. Kasper, A. Azami, R. Peralta, M. Johnson, J. A. Bakall, E. Barron Villalobos, E. C. Ross, J. A. Szivek, D. S. Margolis, P. Gutruf, <i>Nat. Commun.</i> <b>2021</b>, <i>12</i>, 6707.<br/>[7] A. Burton, S. N. Obaid, A. Vázquez-Guardado, M. B. Schmit, T. Stuart, L. Cai, Z. Chen, I. Kandela, C. R. Haney, E. A. Waters, H. Cai, J. A. Rogers, L. Lu, P. Gutruf, <i>Proc. Natl. Acad. Sci.</i> <b>2020</b>, 201920073.