Manoj Kumar Sharma1,2,Dan Chang2,Jingjing Qu2,Hao Song2,Chengzhong Yu2,Ashok Kumar Ganguli1,Jie Tang2
IIT Delhi1,The University of Queensland2
Manoj Kumar Sharma1,2,Dan Chang2,Jingjing Qu2,Hao Song2,Chengzhong Yu2,Ashok Kumar Ganguli1,Jie Tang2
IIT Delhi1,The University of Queensland2
Nanotechnology has emerged as a promising field in treating various diseases, offering significant advancements in drug delivery systems (DDS).<sup>[1]</sup> These systems offer advantages such as improved drug bioavailability, controlled release kinetics, and prolonged circulation time, leading to increased safety and efficacy. Mesoporous Silica (MSN)-based carriers exhibit desirable properties, including high porosity, biocompatibility, and tunable particle size. The introduction of spiky nanotopography on silica nanoparticles has garnered significant scientific interest due to its unique capabilities, including enhanced bacterial adhesion, intracellular drug delivery, and protection of genetic material.<sup>[2]</sup> Nonetheless, challenges persist in MSN-based DDS, encompassing limitations such as low drug loading capacity and premature release of anticancer agents.<sup>[3]</sup> To address these challenges, promising strategies have been explored, such as functionalizing silanol groups on mesoporous silica nanoparticles (MSN) with amine moieties or integrating organic compounds and metal-organic frameworks (MOFs). The literature provides limited information on silica-Zn-MOF composites. Previous studies have predominantly focused on ZIF-8 formation on silica nanoparticles.<sup>[4]</sup><br/>This study successfully synthesized a novel nanocomposite consisting of nature-inspired spiky silica nanoparticles (SNP) embedded with zeolitic imidazolate framework-90 (ZIF-90). The resulting SNP-ZIF-90 composites retained their spiky morphology and demonstrated enhanced drug-loading capacity for doxorubicin (Dox) compared to bare SNP. Furthermore, the modified SNP-ZIF-90 composites exhibited improved cellular uptake and pH-responsive drug release, highlighting their potential as an efficient drug delivery system.<br/><b><u>References</u></b><br/>[1] E. Blanco, H. Shen, M. Ferrari, <i>Nature biotechnology </i><b>2015</b>, <i>33</i>, 941-951.<br/>[2] H. Song, M. Yu, Y. Lu, Z. Gu, Y. Yang, M. Zhang, J. Fu, C. Yu, <i>Journal of the American Chemical Society </i><b>2017</b>, <i>139</i>, 18247-18254.<br/>[3] F. Tang, L. Li, D. Chen, <i>Advanced materials </i><b>2012</b>, <i>24</i>, 1504-1534.<br/>[4] Y. Wang, H. Song, C. Liu, Y. Zhang, Y. Kong, J. Tang, Y. Yang, C. Yu, <i>National Science Review </i><b>2021</b>, <i>8</i>, nwaa268.