Chinedum Osuji1,Ying-Wei Yang1
Jilin University1
Chinedum Osuji1,Ying-Wei Yang1
Jilin University1
The design, synthesis, recognition, and assembly of functional macrocyclic receptors have been playing a critical role in supramolecular chemistry. Due to their superior properties and functions, supramolecular macrocycles, including cyclodextrins, cucurbiturils, calixarenes, and pillararenes, have attracted broad attention in the fields of organic supramolecular chemistry and materials science. Meanwhile, nanoparticles with unique characteristics and particular properties, such as mesoporous silica nanoparticles, metal-organic frameworks, gold nanoparticles, magnetic nanoparticles, and semiconductor nanocrystals, have shown ever-increasing importance in chemistry, materials science, nanoscience, and biomedicine. Upon combining the porous/nonporous inorganic solid nanoplatforms or even organized organic/polymeric nanosystems with supramolecular macrocycles, there is great potential to enhance the photophysical, chemical, electronic, and other related properties of solid supports and the host-guest property of supramolecular macrocycles expanding and advancing the applications of the resulting organic-inorganic hybrid materials.<sup>1-8</sup> In this talk, I will present our methodology and research progress of the chemical construction of smart supramolecular drug delivery systems hybridized with synthetic macrocycles and nanoparticles and showcase their applications in the areas of antimicrobial, anticancer, cell imaging, crop protection, biosensing, etc.<br/><b>References</b><br/>1. Wu, J.-R.; Wu, G.; Yang, Y.-W. <i>Acc. Chem. Res. </i><b>2022</b>, <i>55</i>, 3191−3204.<br/>2. Li, Z.; Yang, Y.-W. <i>Acc. Mater. Res.</i> <b>2021</b>, <i>2</i>, 292–305.<br/>3. Yue, L.; Yang, K.; Lou, X.-Y.; Yang, Y.-W.; Wang, R. <i>Matter</i> <b>2020</b>, <i>3</i>, 1557–1588.<br/>4. Li, Z.; Song, N.; Yang, Y.-W. <i>Matter</i> <b>2019</b>, <i>1</i>, 345–368.<br/>5. Yang, J.; Dai, D.; Zhang, X.; Teng, L.; Ma, L.; Yang, Y.-W. <i>Theranostics</i> <b>2023</b>, <i>13</i>, 295–323.<br/>6. Lou, X.-Y.; Zhang, G.; Song, N.; Yang, Y.-W. <i>Biomaterials</i> <b>2022</b>, <i>286</i>, 121595.<br/>7. Lou, X.-Y.; Yang, Y.-W. <i>Aggregate</i> <b>2020</b>, <i>1</i>, 19–30.<br/>8. Song, N.; Lou, X.-Y.; Ma, L.; Gao, H.; Yang, Y.-W. <i>Theranostics</i> <b>2019</b>, <i>9</i>, 3075–3093.