Implantable Graphene Electrode for Diagnosis and Treatment of Brain Diseases

Various electrophysiological and imaging techniques have been studied for the diagnosis and treatment of brain diseases such as epilepsy. In particular, electrocorticography (ECoG) provides valuable information that can guide clinical treatment in patients with brain diseases. In this talk, we report a highly flexible graphene electrode that stably wraps onto the cortex surface of the brain, exhibiting a remarkable signal-to-noise ratio and providing enhanced data quality. The graphene multichannel electrode successfully detects brain signals with high-throughput spatiotemporal resolution. Furthermore, the exceptional flexibility of graphene electrodes enables the fabrication of injectable electrodes that can be introduced through tiny skull openings. These injectable electrodes allow precise measurement of ECoG signals without the need for extensive surgical procedures. The results highlight the immense potential of flexible graphene electrode array in improving both diagnostic capabilities and therapeutic interventions for brain diseases. This technology holds promise for revolutionizing current treatment strategies and opening new avenues for effectively managing various medically significant brain diseases.