Soft Actuator-Assisted Minimally Invasive Peripheral Nerve Interfaces

Peripheral nerve interfacing has emerged as a highly promising therapeutic technology in various applications, including prosthetic limbs, chronic pain modulation, and the treatment of visceral organ disorders. However, current electrode designs present challenges related to complex handling and implantation-associated irreversible neural damage. This abstract proposes an alternative approach by introducing novel actuatable electrodes that might address these limitations. Our research leverages recent advancements in thin film bioelectronics and soft robotics to develop thin, flexible, and importantly, shape-morphing nerve cuff electrodes. The microfabricated device allows for programming the shape of the electrodes, enabling it to enclose the nerve while maintaining the flexibility to loosen or tighten as needed. This feature ensures a close-fitting conformal interface between the electrode and the nerve, meanwhile enabling straightforward and minimally invasive device explantation steps. Our work presents a promising pathway towards the development of bioelectronic devices that can be manipulated by surgeons to enhance the minimally invasive nature of neurosurgery while achieving optimal electrode-nerve interactions.