Development of Easily Integrable, Cheap, Flexible, 4x4 and 8x12 Arrays of Organic Water-Gated Transistors for Biosensing Applications

Digitizing biomarkers analysis by quantifying them at the single-molecule level is the new frontier for advancing the science of precision health. Such an occurrence will enormously enhance their ability of curing diseases by supporting better prognosis and permitting the application of precise treatment methods.<br/>The SiMBiT project will develop a bio-electronic smart system leveraging on an existing lab-based proof-of-concept that can perform single-molecule detection of both proteins and DNA bio-markers [1] in a minimal sample volume, with enhanced sensing capabilities. In its final shape, it comprises a 96-well plate with the electrolyte gated organic transistors (EG-TFTs) sensing array and the bio-functionalized gates module along with addressing and front-end electronics and an electronic plate reader.<br/>Within this project, 4x4 and 8x12 arrays of EG-TFTs have been produced using scalable, large area compatible processes, and characterized in terms of performances, reproducibility and stability. Several organic semiconductors have been inkjet-printed and used as active materials for the arrays, ranging from the well-established and commercially available P3HT, to polymer-wrapped carbon nanotubes, to a modified PNDIT2 with glycolated side chains, proving the potential of such matrices not only as biosensing platforms, but also as powerful systems for the study and manufacturing of organic electronic functional materials and devices.