Lkhagvasuren Munkhchuluun1,Nomin Tserendulam1,Zolzaya Naranbaatar1,Ankhbayar Enkhbaatar2,Munkh-Erdene Erdene-Ochir1,Tegshjargal Khishigjargal1,Ganzorig Chimed1
National University of Mongolia1,Second State Central Hospital2
Lkhagvasuren Munkhchuluun1,Nomin Tserendulam1,Zolzaya Naranbaatar1,Ankhbayar Enkhbaatar2,Munkh-Erdene Erdene-Ochir1,Tegshjargal Khishigjargal1,Ganzorig Chimed1
National University of Mongolia1,Second State Central Hospital2
Antibiotic resistance has the potential to affect people at any stage of life, as well as the healthcare, veterinary, and agriculture industries, making it one of the world’s most urgent public health problems. Each year in the U.S., at least 2.8 million people are infected with antibiotic-resistant bacteria or fungi, and more than 35,000 people die as a result. No one can completely avoid the risk of resistant infections, but some people are at greater risk than others (for example, people with chronic illnesses). If antibiotics lose their effectiveness, then we lose the ability to treat infections and control public health threats. Many medical advances are dependent on the ability to fight infections using antibiotics, including joint replacements, organ transplants, cancer therapy, and treatment of chronic diseases like diabetes, asthma, and rheumatoid arthritis.<br/>In this research, cuprous oxide nanoparticles were synthesized and integrated into graphene nanocomposites, which were then used to fabricate thin films on a glass substrate. Physicochemical characterizations, antibiotics resistance and antibacterial properties of the thin films were investigated.<br/>Cuprous oxide nanoparticles (Cu2O NPs) were synthesized using sonochemical method. Nanoparticles were integrated into graphene to form nanocomposites via thermal method. Cuprous-oxide and graphene nanoparticles were characterized using UV-Vis spectrophotometry, Photon Cross-correlation Spectroscopy (PCCS), X-ray Diffraction (XRD) and Energy-Dispersive Spectroscopy (EDS). Chemical compositions of nanoparticles and nanocomposites were analyzed by Fourier-Transform Infrared Spectroscopy (FTIR). Then, cuprous oxide nanocomposite thin films were spray-coated on a glass substrate. Antibacterial activity of fabricated thin films were tested against E.coli and S.aureus (MRSA) strains.<br/>Graphene-Cuprous oxide nanocomposites efficiently killed bacteria, including MRSA strains. Graphene-Cuprous oxide nanocomposite thin films have shown antibacterial activity against both Gram-positive and Gram-negative bacterial strains. These findings can be further implemented for the development of antibacterial surfaces.