A Breakthrough in Nanotechnology-Enhanced Glucose Sensors

According to the International Diabetes Federation (IDF), 537 million adults worldwide suffered from diabetes in 2021, and it is expected that by 2045, one out of every eight adults will have diabetes. As a result, monitoring blood glucose concentrations is essential.<br/> <br/>Recent breakthroughs in materials science have led to the creation of nanozymes, which mimic the catalytic functions of natural enzymes, typically comprising metals, metal oxide or metal-organic frameworks (MOFs), offering benefits of stability, precision, and rapid reaction rates for blood glucose measurement.<br/> <br/>Nanozymes, though versatile, tend to lack the specificity of natural enzymes, limiting their practicality, and some may exhibit low biocompatibility.<br/> <br/>Hence, we created enzyme nanoparticles, fusing nanomaterial attributes with enzyme benefits to preserve natural enzyme advantages and compensate for nanozyme limitations like reduced catalytic activity, specificity, and biocompatibility, tailored for utilization in glucose sensors.<br/> <br/>The findings illustrate that by incorporating organic enzyme-based nanoparticles, the electrode can attain outstanding glucose detection capabilities through the utilization of nanotechnology, enabling reduced enzyme dosage, heightened reaction efficiency, and enhanced stability, thus presenting a promising prospect for the future development of a novel blood glucose sensor.