Nanoscale Infrared Spectroscopy Reveals Non-Specific Binding Mechanism of Edaravone—The Next Possible Drug to Cure Alzheimers

The research on Alzheimer is one of the most popular topics across the labs worldwide where much time is spent to test candidate drugs. Edaravone is one such inorganic salt insoluble in water sold under the brand name Radicava. In our research, Edaravone was incubated with Amyloid-β₄₀ in four different ratios and samples were collected at different times. The results clearly demonstrated lesser fibrils when an increased amount of Edaravone was present. Further, we were able to study the interaction between Amyloid-β₄₀and Edaravone using neaspec’s popular nano-FTIR method. We found that Edaravone uniformly and non-specifically binds to Amyloid-β fibrils.