Designed Synthesis and Assembly of Inorganic Nanomaterials for Medical and Healthcare Applications

Over the last 20 years, our laboratory has focused on the designed chemical synthesis, assembly and medical applications of uniform-sized nanocrystals. We demonstrated that ceria nanoparticles and ceria–zirconia nanoparticles can work as therapeutic antioxidants to treat various nasty diseases, including ischemic stroke, Alzheimer’s disease, sepsis, and Parkinson’s disease, rheumatoid arthritis, and radioprotectants.¹We developed a click reaction-assisted immune cell targeting (CRAIT) strategy to deliver drug-loaded nanoparticles deep into tumor interiors, reducing tumor burden in an aggressive 4T1 breast cancer model without any systemic toxicity.² We synthesized MnFe₂O₄-anchored mesoporous silica nanoparticles to overcome hypoxia, and consequently enhancing the therapeutic efficiency of photodynamic therapy.³ We reported a heterogeneous chemodynamic therapy system based on copper-iron peroxide nanoparticles (CFp NPs) for tumor microenvironment-mediated synergistic cancer therapy.⁴ We report a highly sensitive and selective K⁺ nanosensor that can quantitatively monitor extracellular K⁺concentration changes in the brains of freely moving mice experiencing epileptic seizures.⁵<br/>We fabricated ultraflexible and/or stretchable soft-electronic and optoelectronic devices integrated with various functional nanomaterials and their applications to wearable and implantable medical and healthcare devices.⁶ We introduced electromechanical cardioplasty using an epicardial mesh made of electrically conductive and elastic Ag/Au nanowire-rubber composite material to resemble the innate cardiac tissue and confer cardiac conduction system function.⁷ We fabricated highly conductive and elastic nanomembrane for skin electronics.⁸ We synthesized a flexible, sticky, and biodegradable electronic patch for controlled drug delivery for GBM treatment.⁹ We developed a microneedle-based delivery method of theranostic NPs and high-energy photons to treat two types of brain tumors.¹⁰ Recently, we synthesized an injectable hydrogel nanocomposite for intracortical drug delivery to treat deep-seated brain tumors.¹¹<br/><br/>1. a) <i>Angew. Chem. Int. Ed</i>. <b>2012</b>, 51, 11039; b) <i>ACS Nano</i>,<b> 2016</b>, 10, 2860; c) <i>Angew. Chem. Int. Ed. </i><b>2017</b>, 56, 11399; <i>Angew. Chem. Int. Ed. </i><b>2018</b>, 57, 9408; e) <i>Adv. Mater</i>. <b>2018</b>, <i>30</i>, 1807965; f) <i>Adv. Mater</i>. <b>2020</b>, <i>32</i>, 2001566; ACS Nano <b>2019</b>, <i>13</i>, 3206.<br/>2. <i>J. Am. Chem. Soc.</i> <b>2017</b>, <i>139</i>, 10992.<br/>3. <i>J. Am. Chem. Soc.</i>, <b>2019</b>, <i>141</i>, 13829.<br/>4. ACS Nano <b>2022</b>, <i>16</i>, 2535.<br/>5. <i>Nature Nanotechnol.</i> <b>2020</b>, <i>15</i>, 321.<br/>6. a) <i>Adv. Mater.</i> <b>2016</b>, 28, 1176; b) <i>Adv. Mater.</i> <b>2016</b>, 28, 4203; c) <i>Chem. Soc. Rev.</i> <b>2019</b>, <i>48</i><b>,</b> 1566; d) <i>Chem. Rev.</i> <b>2022</b>, <i>122</i>, 5, 5068.<br/>7. a) <i>Science Transl. Med.</i> <b>2016</b>, 8, 344ra86; b) <i>Nature Nanotech</i><i>nol</i><i>.</i> <b>2018</b>, 13, 1048.<br/>8. <i>Science</i> <b>2021</b>, 373, 1022.<br/>9. <i>Nat. Commun<b>.</b></i><b> 2019</b>, <i>10</i>, 5205.<br/>10. <i>Adv. Mater.</i> <b>2021</b>, <i>33</i>, 2100425.<br/>11. “Penetrative and sustained drug delivery using injectable hydrogel nanocomposites for post-surgical brain tumor treatment”, <i>Submitted.</i>