Three-Dimensional Transistor Arrays for Cellular Recording

Recording cellular electrical activities is critical for understanding pathologies and better therapeutic outcomes. This field is currently limited by the tools available for recording the cells. Existing techniques are either lack of accuracy or unable to scale up to record multiple cells simultaneously. In this presentation, I will show a vertically aligned needle-shaped field effect transistor array. I will go through its fabrication strategies, discuss the electrical characterizations, and demonstrate its use in interfacing cultured cells and organoids. Using the transistor array, we were able to directly record signal transport within one cell and among a cellular network, with high spatial and temporal resolutions. Those results hold implications for a wide range of fundamental studies and clinical applications.