Mineral: Peptide Interactions: Using Our Understanding of Molecular Interactions to Develop a Time Efficient Biopanning Approach

Minerals and biomolecules can interact via a range of binding modalities from electrostatic interactions, though hydrogen bonding to hydrophobic interactions and van der Waals interactions. These binding possibilities lead to a range of biomolecule sequences that can interact with a particular mineral. From our understanding of peptide-mineral interactions gained by extensive, detailed experimental and computational studies we have developed an optimised biopanning approach, utilising multiple chemical eluants that allows the identification and recovery of a wide mineral binder pool in just one or two biopanning rounds.