Shape-Programmable Three-Dimensional Microfluidics

Microfluidic devices are gaining extensive interest due to their potential applications in wide-ranging areas, including lab-on-a-chip devices, fluid delivery, and artificial vascular networks. Most current microfluidic devices are in a planar design with fixed configurations once formed, which limits their applications such as in engineered vascular networks in biology and programmable drug delivery systems. In this talk, I will discuss our recent efforts in shape-programmable three-dimensional (3D) microfluidic structures, which are assembled from a bilayer of channel-embedded polydimethylsiloxane (PDMS) and shape memory polymers (SMPs) via compressive buckling. 3D microfluidics in diverse geometries including those in open-mesh configurations are presented. In addition, they can be programmed into temporary shapes and recover their original shape under thermal stimuli due to the shape memory effect of the SMP component, with fluid flow in the microfluidic channels well maintained in both deformed and recovered shapes. By adding magnetic particles into the PDMS layer, magnetically responsive 3D microfluidic structures are enabled to achieve fast, remote programming of the structures via a portable magnet. A design phase diagram is constructed to show the effects of the magnetic PDMS/SMP thickness ratio and the volume fraction of magnetic particles on the shape programmability of the 3D microfluidic structures. The developed shape-programmable, open-mesh 3D microfluidic structures offer many opportunities for applications including tissue engineering, drug delivery, and many others.