Multiscale 3D Printing of Nanomaterials-Based Biomedical Electronics and Ingestible System

The synergistic integration of nanomaterials with 3D printing can enable the creation of architecture and devices with an unprecedented level of functional integration. My research focuses on the multiscale integration of nanomaterials in an extrusion-based 3D printing process,¹ enabling the creation of unique functional bioelectronics² that can address unmet clinical needs.³ As an example, I will first highlight the development of 3D printed quantum-dots light-emitting diode, which extended the reach of 3D printing and demonstrated that active electronics can be entirely 3D printed. In the second part of the talk, I will highlight the development of a 3D printed gastric resident electronics system, which leverages the significant space and immune-tolerant environment available within the gastrointestinal tract to circumvent the potential complications associated with surgically placed medical implants; and explore the possibility of integrating reinforcement learning algorithm to adapt to environmental changes.⁴ Ultimately, we strive to address unmet clinical needs by creating 3D printed free-form biomedical electronics that can better-interface with a broad range of three-dimensional systems.<br/>1. Elder, B., Neupane, R., Tokita, E., Ghosh, U., Hales, S., <b><u>Kong, Y. L.*</u></b> Nanomaterial patterning in 3D printing. <i>Adv. Mater.</i> 1907142 (2020). doi:10.1002/adma.201907142<br/>2. Hales, S., Tokita, E., Neupane, R., Ghosh, U., Elder, B., Wirthlin, D. S., <u><b>Kong, Y. L.*</b></u> 3D Printed nanomaterial-based electronic, biomedical, and bioelectronic devices. <i>Nanotechnology</i> <b>31</b>, 172001 (2020). doi:10.1088/1361-6528/ab5f29<br/>3. Ghosh, U., Ning, S., Wang, Y., <u><b>Kong, Y. L.*</b></u> Addressing unmet clinical needs with 3D printing technologies. <i>Adv. Healthc. Mater.</i> 1800417 (2018). doi:10.1002/adhm.201800417<br/>4. Elder B, Zou Z, Ghosh S, Silverberg O, Greenwood TE, Demir E, Su VS, Pak OS, <u><b>Kong, Y. L.*</b></u> A 3D Printed self-learning three-linked-sphere robot for autonomous confined-space navigation. <i>Adv. Intell. Syst.</i> 2100039 (2021). doi:10.1002/aisy.202100039