Tzu-Li Liu1,Jinghua Li1
Ohio State University1
Monitor biomolecule in bodily fluid plays an important role of reflecting health status and medical treatment. However conventional approaches rely on in-lab equipment or complex wireless electronics, which typically need battery source or complex circuits, and limit the use of real-time monitoring and bio-integrated applications. We aimed to bridge the gap between biochemical sensing and wireless electronics.<br/><br/>We have developed a class of inductor-capacitor (LC) chemical sensors inspired by radio frequency (RF) tuning circuits. The wireless flexible circuit can seamlessly integrate with bio tissue/ personal accessories due to its flexible, concise, and battery-free circuit. Compared to the conventional LC circuit, in which the biochemical sensing interface needs to be within the transmitter, our design can modulate into two function parts: an antenna coupler, that separately encapsulates, and an extended biochemical sensing interface, that can be direct contact with the targeted region.<br/><br/>We have demonstrated its universal sensing capability by using common bio-sensitive elements (e.g., ion-selective membranes, aptamers, and enzymes) on the sensing interface. We also demonstrate its multifunctionality as a sensor metric, which allows the detection of multiple biomarkers simultaneously. The demonstration as “smart accessories” and “miniaturized probe” based on this methodology suggests its broad capability in advanced wireless scenarios.