Design and Fabrication of a Highly Sensitive and Selective Non-Enzymatic Glucose Sensor by a Nafion-Modified Nanoporous Platinum Electrode

lzheimer's disease has been reported to be related to the level of glucose concentration in the brain. This study develops a non-enzymatic glucose sensor using a nanoporous platinum electrode. First, we decorate nanoporous platinum on a commercial gold electrode by cyclic voltammetry electrodeposition. Then, we further modified Nafion on the surface of nanoporous platinum to improve the selectivity of the glucose sensor. We characterize the Nafion-modified nanoporous platinum electrode's morphology, crystallinity, and composition by SEM, XRD, and FTIR, respectively. We evaluate the glucose sensor by electrochemical methods, including cyclic voltammetry, chronoamperometry, and electrochemical impedance spectrum in an artificial cerebrospinal fluid (ACSF). The nanoporous platinum and Nafion-modified nanoporous platinum show their sensitivities of 38.31μAcm^-2mM^-1 and 27.42μAcm^-2mM^-1in ACSF, respectively. Additionally, the Nafion-modified nanoporous platinum remains desirable sensitivity and presents excellent selectivity to interferences, including dopamine (DA), ascorbic acid (AA), fructose, and lactose.