11:45 AM - SB10.12.05
Griseofulvin/Cyclodextrin Inclusion Complex Nanofibers for Fast-Dissolving Oral Drug Delivery Systems
Emmy Hsiung1,Asli Celebioglu1,Tamer Uyar1
Fast-dissolving oral drug delivery systems are gaining more interest in the pharmaceutical industry as a means of administering active pharmaceutical ingredients through tablets, films, and, recently, electrospun nanofibrous webs [1,2]. The large surface area and highly porous structure of nanofibrous webs make nanofibers a promising means of drug delivery, as they readily dissolve in the oral cavity [3-5]. Cyclodextrins (CDs) are classified as cyclic oligosaccharides and are used in drug formulations to increase the water-solubility of hydrophobic drug molecules via inclusion complexation with the doughnut-shaped cavity of CD molecules [2,6]. In this study, an orally fast-dissolving drug delivery system was developed by incorporating inclusion complexes of Griseofulvin/Cyclodextrin with pullulan—a non-toxic, water-soluble biopolymer—to form nanofibrous webs via electrospinning. Griseofulvin is used widely as an antifungal, but it is poorly water-soluble and suffers from low bioavailability. In this study, hydroxypropyl beta cyclodextrins (HPβCD), which have been already used in the pharmaceutical industry due to its high-water solubility, were used to form inclusion complexes . Through inclusion complexation with HPβCD, the water solubility and thus bioavailability of the drug were enhanced. The electrospinning of Pullulan-Griseofulvin/HPβCD solutions yielded defect-free nanofibers collected in the form of self-standing and flexible nanofibrous webs. The formation of inclusion complexes between cyclodextrin and the drug was confirmed using FTIR and XRD analysis, the thermal analysis of the fibers were examined using DSC and TGA, and increased solubility of the drug after complexation was confirmed with UV-Vis spectroscopy. The generated electrospun nanofibrous webs readily disintegrated when wetted with artificial saliva indicating that electrospun Pullulan-Griseofulvin/HPβCD web could be a promising material as a fast-dissolving oral drug delivery system.
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