Recent advances in materials science and mechanical engineering have enabled high-performance bio-integrated systems in soft, flexible formats. The rise in personalized medical diagnostics and treatments stems from the demand for quick, reliable, and cost-effective healthcare solutions. Wearable and implantable bioelectronic materials and devices have driven innovation, enhancing reliability, reducing infection risks, and broadening applications, revolutionizing conventional clinical procedures. Personalized healthcare has highlighted wearable and implantable devices that meticulously monitor physiological parameters, allowing comprehensive analysis from bodily movements to targeted clinical treatments. The integration of individualized bio-parameters from various organs has transformed healthcare diagnostics. Progress in materials science and device engineering, along with predictive biological models, propels bioelectronics forward. Materials facilitating seamless communication with biological entities have led to new device configurations, enabling the transduction and amplification of biological signals. This synergy between biology and electronics underpins reliable high-content studies and predictive models. This symposium will showcase ultrathin inorganic and hybrid materials for flexible, stretchable, bio-integrated devices, emphasizing their design, materials, mechanical structures, and bioelectronics applications. It will highlight the latest advancements in bioelectronic materials and devices, focusing on controlling bioelectronic interfaces to create durable and functional systems. Sessions will explore strategies for biomedical applications and multifunctional electronic materials interfacing with biology. The symposium aims to provide an overview of cutting-edge bioelectronics developments, particularly their integration into personalized healthcare, fostering interdisciplinary collaboration for transformative healthcare technology and innovation.