Bioinspired Electronics for Brain-Machine Interface

Bioelectronic devices have been very important both as fundamental research tools and as therapeutic avenues for treating brain disorders and injuries. I will talk about how I drew inspiration from biological systems and art forms to design and develop a series of bio-inspired and art-inspired bioelectronics with distinctive biomedical applications. I have introduced bioinspired neuron-like electronics, a biomimetic brain-machine interface designed such that the key building blocks mimic the subcellular structural features and mechanical properties of neurons. I have developed multifunctional vasculature-like electronic scaffolds that guide and longitudinally track neural migration following brain injury. Moreover, we devised flexible kirigami-inspired electronics that transition from a 2D pattern to a 3D basket-like configuration to enable long-term integration and interrogation of human brain organoids and assembloids. Our studies advance bioelectronics in fundamental studies and therapeutic applications, encompassing neural probes for brain-machine interface, electronic scaffolds for brain repair, and platforms for detecting human genetic diseases and tracking human neural development.