Biocompatible 2D Material Inks Enabled by Supramolecular Chemistry

The emergence of two-dimensional (2D) materials, such as graphene, transition metal dichalcogenides, and hexagonal boron nitride has sparked significant interest in various biomedical applications due to their unique physicochemical, optical, electrical, and mechanical properties. However, the interaction of the material with the biological environment is strongly dependent on the surface chemistry and morphology of the crystals, [1] hence it is crucial to develop methods able to finely tune the surface charge and types of functional groups. In this talk I will show that supramolecular chemistry allows to achieve in one-pot approach both liquid-phase exfoliation in water and non-covalent functionalization of the material, hence enabling to produce a wide range of biocompatible 2D materials with specific surface chemistry. [2-5] I will provide seminal biomedical studies based on 2D material produced with the supramolecular approach, ranging from Lysosomal Storage Disorders therapeutics to trained immunity in macrophages and to immune-compatible nanoplatforms for single-cell mass cytometry by time-of-flight.[6-8]<br/><br/>1. Fadeel B, et al. Acs Nano. 2018;12(11):10582<br/>2. Hu C-X, et al. Nanoscale. 2021;13(2):460<br/>3. Shin Y et al, Faraday Discussions. 2021;227(0):46<br/>4. Shin Y, et al. Molecular Systems Design & Engineering. 2019;4(3):503<br/>5. Shin Y, et al. Nanoscale 2020, 12, 12383<br/>6. Chen Y, et al. Nanoscale. 2023;15(21):9348<br/>7. Peng G, et al. Small. 2022;18(20):2107816.<br/>8. Gazzi A, et al. Nano Today. 2024;54:102084.