Long-Term Stable Biochemical Sensing Platform in Complex Biological Environment

Continuous monitoring of specific clinically-relevant analytes in situ would offer exciting capabilities for fundamental research and clinical medicine. However, achieving this capability has proven difficult due to biofouling, probe degradation and signal drift that often occur within complex biological environments. Our solution leverages the nanoporous biosensors (npAu), and demonstrated its ability to sustain prolonged small molecule sensing both in vitro and in vivo while mitigating fouling and signal degradation. We believe the nanostructure design could provide the foundation for a new generation of long-term stable biosensors.