Next-generation devices and products are trending towards economically and environmentally favorable thin and lightweight biomaterials, opening new opportunities for scientific, social, and industrial benefits. Novel materials and their applications should perform adequately under required environment to be viable; systematic studies under extreme conditions in the various points of view are in need of more attention: optimization of electronics manufacturing and packaging technique, device functionality, and reliability assessment. To this end, this symposium will focus on the reliability aspects of testing the latest biomaterials and applications under extreme conditions. First, we will introduce recent advances in thin-film applications and the effort made towards viability: medical products, implantable/wearable electronics, bioelectronics, RF devices, smart packaging, bioproducts, green electronics, and energy harvesting. Other recent applications in food and pharmaceuticals, composite materials in the engineering of all kinds, gaining attention as future products, are welcomed. Another focus of this symposium is on developing diffusion barrier materials used in the packaging and encapsulation of these applications. Hermetic encapsulations using nanocomposite materials with thin film deposition and processing technologies, (e.g. vacuum processed depositions, polymer processing of 2D nanoparticles) can potentially reach a lifespan of several years to decades under implanted conditions. Such barrier materials are processed with flexible organic matrices and/or substrates to improve reliability. Discussion of various quality control methods used in the lifetime and performance evaluation will be welcomed. Examples include corrosion test, leakage current monitoring, and high temperature and electro-mechanical fatigue cycling of conductive functional layers. This symposium aims at gathering researchers interested in viable next-generation biomaterial and thin-film applications, bridging the gap between lab-based prototypes and ones available off the shelf.