Simple, controllable, and versatile access to the intracellular space with minimal perturbation is crucial to advancing biomedicine. Emerging materials, such as nanoneedles and nanomechanical cell squeezers—are transforming our capacity to sample, sense, perturb, control and deliver to the intracellular environment, and rapidly translating to impact cell and gene therapy, mechanobiology, spatial biology, and neural interfaces. The symposium aims to establish an essential discussion across the relevant research communities in micro- and nano-fabrication, biomaterials design, bioengineering, advanced therapies and medical device manufacturing across three areas: First, the design and manufacturing of devices for cell manipulation including theory and practice of device design and its integration with electronics, fluidics and mechanics; manufacturing methods; control of physical and chemical properties; technology-readiness progress. Second, biointerface design, including analytical, numerical, and machine learning modelling to predict interactions; biomaterial design and surface modifications; characterisation of the biointerface.
Third, biomedical applications including intracellular delivery; intracellular biosensing; biophysical interrogation. The symposium will discuss the potential market, the scale of interest and investment, regulatory issues with input from biomedical industry leaders.

bioelectronic biomaterial biomedical devices modeling nanoscale nanostructure