High-entropy materials (HEMs) has become an exciting and vibrant field of materials science as a new generation of materials. The HEM design concept, shifts the focus away from the corners of phase diagrams toward their centers, allows compositions beyond the scope of traditional materials, offering unprecedented properties, challenges and opportunities for a wide range of structural and functional applications. Although we understand HEMs much better today, there are still significant gaps in our knowledge that hinder widespread uses of HEMs. The goal of this symposium is to share the latest research advances in materials with high configurational entropy, including high-entropy and complex concentrated alloys, high-entropy oxides/ nitrides, high-entropy metallic glasses, etc. and discuss major materials issues for HEMs from property-targeted design to process optimization, from structures to properties, and from the fundamental science to viable industrial applications. This symposium will cover fundamental theory and data-driven material design, fabrication, processing and microstructure control, such as homogenization, precipitation, nanostructure, and grain-boundary engineering using conventional equipment, combinatorial fabrication, additive manufacturing etc, phase stability and diffusivity under extreme environment, mechanical behavior under different deformation mechanisms, corrosion, physical, magnetic, electric, thermal, coating, and biomedical behavior, advanced characterization, such as synchrotron, three-dimensional atom probe and 4-D STEM, computational modeling and simulations, and industrial applications, such as structural, mechanical, biomedical, energy applications. In this symposium, we hope to deepen understanding of why HEMs attract such intensive interest, as well as highlight some challenging issues awaiting resolution to provide viable paths to widespread application and adoption of HEMs.