The emerging challenge in enabling engineering tissue components is in simulating the natural and organizational complexity of biological tissues. An important aspect in succeeding the above goal rests with Biofabrication, which involves the formation of tissue-like structures composed of biomaterials and cells through fabrication and manufacturing procedures. Such an ongoing development is also hoped to accelerate the translation of biomaterials and cell-based products towards clinical and scaled-up applications.
Current biofabrication technologies, ranging from inkjet printing to robotic dispensing, allow researchers to design and build structures with increasing versatility and precision. From a material scientist’s prospective, it remains a challenge to develop unique hydrated materials for bio-inks, which can simultaneously satisfy the required biological competence, and the physical requirements for processing. The biological competence considers biocompatibility, bioactivity, and the potential of controlled nutrients and growth factor release. The processing properties are commonly related to those used in additive manufacturing, such as the ink’s rheology and crosslinking or hardening mechanisms. Throughout, one also needs to consider how the processing effects may change the materials contents, and methods to minimize the degradation.
The aim of this symposium is to disseminate enabling technology which bridges the gap between biofabrication and manufacturing biomaterial-tissue components. In this symposium, the applications of biofabricated devices and organ-on-chips will be also discussed. Interdisciplinary topics related to materials science, bioengineering, regenerative medicine and manufacturing will be connected by invited talks in order to accelerate the development of biofabricated biologic and synthetic materials toward clinical applications.