Chiral Vanadium Oxide Nanoclusters with Predictive Docking and Biomimetic Actin Polymerization

Polyoxovanadate had been studied in many biological systems, and demonstrated many effective activities, but due to the flexible evaluation of the speciation, there always has more than one oligomer/species existed in the solution simultaneously.^[1] Decavanadate (V10), as one of the polyoxovanadate species, have many unique biological effects compared to other oligomers, for instance the interaction with Actin. ^[2,3] Up to now, the investigations of decavanadate were based on the initial symmetry structure, and no chiral properties had been inspected to the best of our knowledge. Here, we will present a novel case of chiral decavanadate (Chiral V10), in which the vanadium decamer-core was linked by four chiral tartaric acid ligands. The composition, chemical and optical properties of chiral-V10 were characterized by ESI-TOF, 51V-NMR, Raman, Circular Dichroism spectroscopy and so on. Chiral-V10 presents ATP-mimetic property and assists G-actin polymerization in absence of ATP. Moreover, the formed actin filaments revealed enantiomer-dependent constructions. The exploration of ATP-mimetic chiral-V10 will open new avenue to investigate chiral polyoxovanadates with many biological activities, give new insight into inorganic medicinal chemistry, novel metallodrugs, and artificial muscles manipulation.

References
[1] de Azambuja, F.; Steens, N.; Parac-Vogt, T. N. Metals 2021, 11, 1678.
[2] Aureliano, M.; Crans, D. C. Journal of Inorganic Biochemistry 2009, 103, 536.
[3] Sciortino, G.; Aureliano, M.; Garribba, E. Inorganic Chemistry 2021, 60, 334.