Tissue-Interfaced Organic Bioelectronics

Organic bioelectronics has emerged as a vital field, capitalizing on the distinctive properties of organic semiconductors to interface with biological systems such as cells, tissues, and organs. This presentation will detail the design and fabrication of organic transistors tailored for bio-sensing applications, focusing on human skin, in vivo animal brains, and 3D-bioprinted lung models. The session will commence with the introduction of a flexible array of organic thin-film transistors (OTFTs) characterized by high yield and consistency. This array is integrated with piezoresistive pressure sensors and photodiodes to form a multifunctional sensing platform. We have developed a 3D active-matrix sensor array capable of multimodal spatial sensing of pressure and temperature from a single point, which has been successfully applied to robotic arms, enhancing their tactile feedback capabilities. Further, we delve into the creation of printed organic active neural probes. Through the adoption of additive digital printing technology, we have integrated multiple organic electrochemical transistors (OECTs) with passive components. This integration enables the precise detection of neural activity in the somatosensory cortex, featuring high amplification and minimal noise. Lastly, we will unveil an innovative 3D-bioprinted, tissue-integrated ion-sensing platform employing OECTs. Utilizing inkjet printing techniques, we have engineered large-area OECTs that seamlessly integrate with bioprinted lung tissue constructs. This platform is adept at monitoring and detecting disruptions in tissue tight junctions induced by H1N1 influenza virus infection, showcasing its utility in disease modeling and drug efficacy studies. This presentation will highlight the transformative synergy between organic electronics and biological systems, potentially revolutionizing medical diagnostics, therapeutic strategies, and personalized medicine.