AI Driven Closed Loop Control of Cell Behavior with Bioelectronics

Homeostasis is crucial for sustaining life and regulating biological processes. It is achieved through closed-loop systems, where receptors and effectors work together to maintain equilibrium. Common examples include cardiac rhythms, blood glucose levels, and body temperature regulation. Today, bioelectronic devices can sense and influence physiological processes by converting biological signals—such as ions and small molecules—into electronic signals that can be processed by modern information technologies. In this presentation, I will discuss our work integrating AI-based closed-loop control with sensors and bioelectronic actuators to regulate physiological processes. Specific examples include guiding stem cell differentiation, controlling bacterial growth, and accelerating wound healing.