Wearable Sweat Sensors—New Sensing Modalities and Form Factors

Wearable sensor technologies play a significant role in realizing personalized medicine through continuously monitoring an individual’s health state. To this end, human sweat is an excellent candidate for non-invasive monitoring as it contains physiologically rich information. In this talk, I will present our recent advancements on fully-integrated perspiration analysis system that can simultaneously measure sweat rate, metabolites, electrolytes, drugs and heavy metals, as well as the skin temperature to calibrate the sensors' response. This wearable system is used to measure the detailed sweat profile of subjects at rest and engaged in prolonged physical activities and infer real-time assessment of physiological state of the subjects. Different sensing modalities and form factors will be discussed. Case studies on the correlation of sweat analytes with those of blood and various physiological conditions will be presented, including for applications in dehydration studies, diabetes monitoring, drug metabolism rate studies, and detection and monitoring of cystic fibrosis. Finally, a general roadmap for the technology will be presented, with focus on opportunities and challenges.