Stimuli-Responsive Polymer Particles and Templates—Sensor and Delivery Functions

There is high interest in delivering effective drug delivery systems and pharmacokinetics based on particles and fluidic devices. In particles and nanoparticles, the theranostic applications of enabling specific biomarker targeting with payload delivery are intriguing, especially in cancer treatment applications. The ability to control release profile and stealth targeting are ultimate goals. This talk will highlight the following work: 1) Microfabricated Polymer layered and core-shell particles, 2) hybrid-dendrimeric and hyperbranched polymer grafted nanoparticle delivery systems, and 3) viral and non-viral delivery systems, as demonstrated by our group. The goal is to highlight materials systems that can enable in-vivo and in-vitro applications that can direct applications toward disease treatment or tissue engineering. It is important to demonstrate structure-composition-processing-property (SCPP) relationships that govern the templating and stimuli-responsive materials of predominantly core-shell structures.