Orbit Symmetry Breaking in MXene Implements Enhanced Soft Bioelectronic Systems

Bioelectronic systems with soft mechanics, stable biocompatibility, and high-performance electronic recording and stimulation interfaces to internal organs offer paradigm-shifting potentials for advancing biomedical implants such as those for cardiovascular disease. Yet, challenges remain in the development of biocompatible materials with practical scalability for constructing bioelectronic systems that leverage performance and interfacial attributes to not only functionally approach those of conventional wafer-based technologies but also biologically compatible for long-term in-body operation. Here, we present the orbit symmetry breaking in MXene (a low-cost scalable, flexible, and conductive 2D layered material), implementing the improved electrode-tissue interface impedance, which stems from the out-of-plane charge transfer, and coupling with in-plane high conductivity comparable to precious metals. Besides, we compare MXene bioelectronics with commercial biotraces (gold, graphene oxide, and poly(3,4-ethylenedioxythiophene) polystyrene sulfonate), emphasizing its enhanced biocompatibility, durability, and imaging visibility in bioelectronic systems. Accordingly, we introduce an epicardial patch based on orbit-symmetry-broken MXene that integrates the matrix mapping of electrophysiological activity and therapeutic capabilities across large areas at high-fidelity spatiotemporal resolution. Last, a wireless and battery-free MXene module, combined with real-time recording and closed-loop stimulation, demonstrates high signal-to-noise ratio data transmission, and wireless power transfer within bioelectronic systems.