April 22 - 26, 2024
Seattle, Washington
May 7 - 9, 2024 (Virtual)
Symposium Supporters
2024 MRS Spring Meeting
SB05.05.02

NeuroEdge: Graphene Nanoedge Electronics for Monolithic and Chronic Recording at Neuronal Density

When and Where

Apr 24, 2024
8:30am - 9:00am
Room 434, Level 4, Summit

Presenter(s)

Co-Author(s)

Yuxin Liu1,Yunxia Jin1,John Ho1

National University of Singapore1

Abstract

Yuxin Liu1,Yunxia Jin1,John Ho1

National University of Singapore1
Recording electrophysiological signals from every closely spaced individual neuron over long durations is crucial for understanding the brain micro-circuit and functionalities at the cellular level. However, existing probe technologies are limited by sparse sampling of neurons in the intralaminar plane due to large interelectrode spacing and the need for surface modification materials, which are susceptible to instability over time, in order to have small dimensions and low impedance. Here, we report a monolithic graphene-edge probe array (NeuroEdge) that achieves a density of &gt;2000 electrodes/mm<sup>2</sup>, approaching cortical neuronal density. NeuroEdge is composed of self-aligned reduced graphene oxide nanoflakes with well-exposed nanoedges and electrolyte-filling nanochannels at the end, achieving impedance &lt; 0.2 MΩ at neuronal size. Owing to its monolithic material composition and exceptionally low impedance, NeuroEdge provides stable electrophysiological recording with a high signal-to-noise ratio &gt; 20 dB over 6 months. We demonstrate the utility of NeuroEdge for interrogating closely packed neurons by revealing the heterogeneity of acoustic-triggered activity in mouse auditory cortex. NeuroEdge provides a tool for accurately discriminating spikes from neighboring neurons in microcircuits <i>in vivo</i>.

Symposium Organizers

Eric Glowacki, Central European Institute of Technology
Philipp Gutruf, University of Arizona
John Ho, National University of Singapore
Flavia Vitale, University of Pennsylvania

Symposium Support

Bronze
Diener Electronic GmbH + Co. KG

Session Chairs

Eric Glowacki
Flavia Vitale

In this Session