April 22 - 26, 2024
Seattle, Washington
May 7 - 9, 2024 (Virtual)
Symposium Supporters
2024 MRS Spring Meeting
SB08.03.01

Nonfibrotic Bioelectronic Interfaces with Diverse Organs

When and Where

Apr 23, 2024
2:00pm - 2:30pm
Room 433, Level 4, Summit

Presenter(s)

Co-Author(s)

Xuanhe Zhao1

Massachusetts Institute of Technology1

Abstract

Xuanhe Zhao1

Massachusetts Institute of Technology1
Implanted biomaterials and devices face compromised functionality and efficacy in the long term due to foreign body reactions and subsequent formation of fibrous capsules at the implant-tissue interfaces. Here, we demonstrate that an adhesive implant-tissue interface can mitigate fibrous capsule formation in diverse animal models, including mice, rats, humanized mice, and porcine models, by minimizing the establishment of the inflammatory microenvironment and subsequent infiltration of inflammatory cells at the implant-tissue interface. Histological analysis shows that the adhesive implant-tissue interface does not form observable fibrous capsules on diverse organs, including the abdominal wall, colon, stomach, lung, peripheral nerves, and heart, over 12 weeks in vivo. In vitro protein adsorption, multiplex Luminex assays, quantitative PCR, immunofluorescence analysis, and RNA sequencing are additionally performed to validate the hypothesis. We further demonstrate long-term bi-directional electrical communication enabled by implantable electrodes with an adhesive interface over 12 weeks in a rat model in vivo. This finding may offer a promising strategy for long-term anti-fibrotic implant-tissue interfaces.

Keywords

electron spin resonance | Mössbauer effect | nuclear magnetic resonance (NMR)

Symposium Organizers

Guosong Hong, Stanford University
Seongjun Park, Korea Advanced Institute of Science and Technology
Alina Rwei, TU Delft
Huiliang Wang, The University of Texas at Austin

Symposium Support

Bronze
Cell Press

Session Chairs

Guosong Hong
Alina Rwei

In this Session