Optical Tracing and Inhibition of Metastatic Tumor with Metal Quantum Clusters

Metal quantum clusters, characterized by their ultra-small size of fewer than 100 atoms, represent a promising class of nanomaterials with unique properties such as photoluminescence, high photostability, and water solubility, accompanied by a commendable quantum yield. Among these, gold quantum clusters (GQCs) have garnered significant attention, particularly in the realm of biomedical applications. Their size, below the physiological cut-off limit of 6-8nm, positions GQCs as ideal candidates for in-vivo applications due to their efficient renal clearance. Preliminary findings from our research underscore the potential of GQCs in the field of biomedicine. Notably, GQCs exhibit emission maxima at approximately 800 nm, extending up to 1000nm. This characteristic makes them particularly valuable for optical imaging, offering a wavelength range suitable for penetrating biological tissues. The versatility of GQCs extends beyond their role as imaging agents. Our investigations reveal that GQCs also display a remarkable capacity to inhibit secondary metastasis, specifically in the lungs. This inhibitory effect parallels the efficacy of Doxorubicin, a well-established chemotherapeutic drug used clinically. This dual capability of GQCs – optical imaging and metastasis inhibition positions them as multifunctional tools in the fight against cancerous cells. Moreover, the photostability of GQCs allows for prolonged imaging periods without compromising the quality of signals. Additionally, the water solubility of these clusters enhances their compatibility with biological systems, facilitating their integration into various medical applications. In the context of optical imaging, GQCs offer a distinct advantage. Their unique combination of optical properties, biocompatibility, and therapeutic potential positions GQCs as promising candidates for the development of innovative cancer theranostics