Corona Phase Molecular Recognition of Fluorescent Carbon Nanotube for Theragnostic

Understanding molecular recognition is of fundamental significance in theragnostic. The key to biorecognition lies in unique three-dimensional structures that create binding sites, or interfaces, capable of recognizing a specific molecule such as antibodies or aptamers. We have introduced various synthetic heteropolymers, designed to adsorb onto a single-walled carbon nanotube, forming a specific corona phase that exhibits a highly selective optical response to target analytes. This technique is called Corona-Phase Molecular Recognition (CoPhMoRe). Leveraging the CoPhMoRe technique, we have developed more than 20 nanosensors for hormones, vitamins, neurotransmitters serum proteins, and reactive oxygen species. In this session, we plan to discuss carbon nanotube fluorescent sensors and their potential in cancer diagnostics. We have created a novel polymer library to engineer the corona phase of carbon nanotubes. An array of selected nanosensors exhibits the ability to distinguish cancer biomarkers. Lastly, we will introduce a novel two-dimensional (2D) polymeric material that is chemically stable and highly processable. These 2D polymeric materials exhibit strong fluorescence that may have significant value in future sensing and imaging applications