Amyloid-β and Mucin Debris Removal Using Magnetite-Ceria Nanoparticle Assemblies for Alzheimer's Disease and Pseudomyxoma Peritonei

The presence of Aβ protein in the brain significantly contributes to Alzheimer's disease progression, while mucin accumulation in Pseudomyxoma Peritonei (PMP) cancer obstructs drug delivery, emphasizing the need for its removal to enhance treatment effectiveness. We introduce an Aβ cleansing system utilizing multifunctional magnetite/ceria nanoparticle assemblies for targeted removal of Aβ peptides from circulating blood through specific capture and magnetic separation. The magnetite nanoparticles in the core of these assemblies enable the magnetic isolation of captured Aβ peptides, exerting a strong attractive force under an external magnetic field. Concurrently, ceria nanoparticles in the shell alleviate oxidative stress by scavenging reactive oxygen species generated during immune responses. Application of this blood Aβ cleansing system in 5XFAD transgenic mice not only reduces Aβ levels in both blood and brain but also prevents spatial working memory deficits, indicating its potential for Alzheimer's disease prevention and therapy. This technology is also applied to reduce mucin debris in an ascites PMP mouse model.