Magnetogenetic Stimulation Modulates Cortico-Basal Ganglia-Thalamic Circuit in Hemi-Parkinsonian Mice

Magnetogenetic deep brain stimulation (MG-DBS), utilizing nanoscale magnetic actuators, has recently emerged as a promising strategy for treating motor disorder of Parkinson’s disease (PD). This innovative approach offers extended recovery durations, while providing cell-specific, fully wireless treatment, addressing the limitations of conventional electrical deep brain stimulation (E-DBS). In this study, we employed a phase-changeable soft neural probe, based on a liquid-metal electrode, to collect electrophysiological signals from the cortico-basal ganglia-thalamic (CBT) circuit in PD mouse brain. This probe minimizes disruption to the neural network within the CBT circuit, enabling precise and comprehensive electrophysiological analysis. By monitoring neural activity changes across six major regions of the CBT circuit, we thoroughly explored the therapeutic effects of MG-DBS. Our electrophysiological analysis not only supports the effectiveness of MG-DBS but also provides valuable insights into the underlying mechanism of DBS therapies. These findings significantly contribute to advancements in the field of neuroscience and neuromodulation therapies.