Biomimetic Polymer Electronics—From Bioadhesive and Immune-Compatible Biosensors to Skin-Like Neuromorphic Circuits

The effective use of electronic devices for acquiring biological information and delivering therapeutic interventions hinges on two key aspects: acquiring physiological data through contact with soft bio-tissues and high-throughput processing using machine learning. Ensuring high-quality signal transduction requires interfaces between bioelectronic devices and bio-tissues that combine signal amplification with stable, conformable contact. Organic electrochemical transistors (OECTs) are advanced technologies for high-performance bio-sensing and neuromorphic computing. However, challenges such as rigid mechanical properties, lack of tissue adhesion, and immune reactions hinder the formation of stable bio-interfaces.<br/>In my talk, I will first present our material and device designs for OECT-based biosensors that incorporate bioadhesive properties, immune compatibility, and tissue-like softness, achieving these biomimetic properties while maintaining state-of-the-art electrical performance. I will discuss the strategies and advantages of using these properties in bioelectrical and biochemical sensing. Additionally, I will cover our research on imparting intrinsic stretchability to neuromorphic devices and circuits, which provide advanced computing performance, demonstrating their practical applicability for machine-learning-based health data analysis.