Real-Time Biosignal Monitoring in In Vivo and In Vitro 3D Tissues with Organic Printed Electrochemical Transistors

This talk explores the development of printed organic electrochemical transistors (OECTs) for interfacing with in vivo and 3D in vitro tissues. Initially, we present tunable organic active neural probe enabling near-sensor signal processing. By utilizing additive inkjet printing technology, we seamlessly integrated multiple OECTs with passive components to detect neural signals from the somatosensory cortex, achieving high gain and low noise performance. We then introduce a pioneering 3D tissue-integrated ion-sensing platform using OECTs. For the first time, inkjet-printed large-area OECTs were integrated with 3D-bioprinted lung tissue models. This platform effectively monitors changes in tissue tight junctions during long-term air-liquid culture and successfully detects disruptions caused by H1N1 influenza virus infection, demonstrating its potential in disease modeling and drug efficacy evaluation. This presentation highlights the synergy between organic electronics and biological systems, highlighting the transformative potential of organic bioelectronics in medical diagnostics, therapeutic interventions, and personalized medicine.